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KMID : 1149220030110020095
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Korean Journal of Oriental Medical Prescription
2003 Volume.11 No. 2 p.95 ~ p.110
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Effect of Anti-Alzheimer’s disease by Jeonmaedan in CT105-overexpressed SK-N-SH cell lines
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Song Ho-Sang
Park Chi-Sang
Park Chang-Gook
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Abstract
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Alzheimer’s disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. Although a variety of oriental prescriptions in study Jeonmaedan have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet fully elucidated. It has been widely believed that Aβ peptide devided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that CTl05(carboxy terminal 105 amino acid peptide fragment of APP) may be an important factor causing neurotoxicity in AD. In addition, AD is one of brain degeneration disease. So we studied on herbal medicine that have a relation of brain degeneration. In Oriental Medicine, Jeonmaedan has been used for disease in relation to brain degeneration. As the result of this study, in Jeonmaedan the apoptosis in the nervous system is inhibited, the repair against the degerneration of SK-N-SH cell lines by CT105 expression is promoted. So Jeonmaedan may be beneficial for the treatment of AD.
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KEYWORD
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Alzheimer’s disease(AD), Jeonmaedan, SK-N-SH cell
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